The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease

Celiac disease is a prevalent autoimmune disorder with rising incidence of 7.5% annually during the second half 20<sup>th</sup> century and 21<sup>st</sup> century. Not all genetically susceptible individuals that carry risk alleles HLA DQ2 DQ8 go on to develop celiac disease, suggesting there may be other environmental triggers contribute development in individuals. Gastroenteritis infancy has been shown associated increased disease. Secretor status, per FUT2 genotype, subsequent alterations microbiota, gastroenteritis infants. This review investigates literature from January 2010 June 2022 determine combined effect secretor status viral disease.<strong> </strong>Mothers phenotype infants non-secretor provided most protection against particular strains Both maternal infant as well infant’s Lewis ABO blood group can influence susceptibility different strains, which cause gastroenteritis. caused by infections damage intestinal epithelial cells, dysbiosis, affect pro-inflammatory cytokines, exacerbate onset. Understanding provide novel approach early screening preventative strategies reduce factors onset